JPH0217524B2 - - Google Patents
Info
- Publication number
- JPH0217524B2 JPH0217524B2 JP18217988A JP18217988A JPH0217524B2 JP H0217524 B2 JPH0217524 B2 JP H0217524B2 JP 18217988 A JP18217988 A JP 18217988A JP 18217988 A JP18217988 A JP 18217988A JP H0217524 B2 JPH0217524 B2 JP H0217524B2
- Authority
- JP
- Japan
- Prior art keywords
- caries
- bacteria
- mutans
- present
- bactericidal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- VVOAZFWZEDHOOU-UHFFFAOYSA-N magnolol Chemical compound OC1=CC=C(CC=C)C=C1C1=CC(CC=C)=CC=C1O VVOAZFWZEDHOOU-UHFFFAOYSA-N 0.000 claims description 22
- BYTORXDZJWWIKR-UHFFFAOYSA-N Hinokiol Natural products CC(C)c1cc2CCC3C(C)(CO)C(O)CCC3(C)c2cc1O BYTORXDZJWWIKR-UHFFFAOYSA-N 0.000 claims description 6
- FVYXIJYOAGAUQK-UHFFFAOYSA-N honokiol Chemical compound C1=C(CC=C)C(O)=CC=C1C1=CC(CC=C)=CC=C1O FVYXIJYOAGAUQK-UHFFFAOYSA-N 0.000 claims description 6
- 239000004075 cariostatic agent Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 208000002925 dental caries Diseases 0.000 description 25
- 230000000844 anti-bacterial effect Effects 0.000 description 18
- 241000894006 Bacteria Species 0.000 description 15
- 241000194019 Streptococcus mutans Species 0.000 description 14
- 239000003795 chemical substances by application Substances 0.000 description 12
- 239000000284 extract Substances 0.000 description 11
- 230000003449 preventive effect Effects 0.000 description 11
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 description 10
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 9
- 238000000034 method Methods 0.000 description 9
- 230000005764 inhibitory process Effects 0.000 description 8
- 230000000694 effects Effects 0.000 description 7
- 239000003814 drug Substances 0.000 description 5
- 229940079593 drug Drugs 0.000 description 5
- 229960003276 erythromycin Drugs 0.000 description 5
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- 230000002378 acidificating effect Effects 0.000 description 4
- 239000003242 anti bacterial agent Substances 0.000 description 4
- 230000001013 cariogenic effect Effects 0.000 description 4
- 229940126678 chinese medicines Drugs 0.000 description 4
- 238000011160 research Methods 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- YBHILYKTIRIUTE-UHFFFAOYSA-N berberine Chemical compound C1=C2CC[N+]3=CC4=C(OC)C(OC)=CC=C4C=C3C2=CC2=C1OCO2 YBHILYKTIRIUTE-UHFFFAOYSA-N 0.000 description 3
- 229940093265 berberine Drugs 0.000 description 3
- QISXPYZVZJBNDM-UHFFFAOYSA-N berberine Natural products COc1ccc2C=C3N(Cc2c1OC)C=Cc4cc5OCOc5cc34 QISXPYZVZJBNDM-UHFFFAOYSA-N 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 230000002401 inhibitory effect Effects 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 229940034610 toothpaste Drugs 0.000 description 3
- 239000000606 toothpaste Substances 0.000 description 3
- 208000002064 Dental Plaque Diseases 0.000 description 2
- 229920001503 Glucan Polymers 0.000 description 2
- 229930006000 Sucrose Natural products 0.000 description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
- 229940088710 antibiotic agent Drugs 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 230000003115 biocidal effect Effects 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- 239000012259 ether extract Substances 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 210000000214 mouth Anatomy 0.000 description 2
- 231100000957 no side effect Toxicity 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 239000005720 sucrose Substances 0.000 description 2
- XVOKPNRYHDZDMX-UHFFFAOYSA-N 1-(4-ethyl-2-bicyclo[2.2.1]heptanyl)cyclohexan-1-ol Chemical compound C1C(CC)(C2)CCC1C2C1(O)CCCCC1 XVOKPNRYHDZDMX-UHFFFAOYSA-N 0.000 description 1
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- 229920002307 Dextran Polymers 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 241000187479 Mycobacterium tuberculosis Species 0.000 description 1
- 229930182555 Penicillin Natural products 0.000 description 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
- 241000607768 Shigella Species 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 241000194017 Streptococcus Species 0.000 description 1
- 241001134658 Streptococcus mitis Species 0.000 description 1
- 241000194023 Streptococcus sanguinis Species 0.000 description 1
- YSVZGWAJIHWNQK-UHFFFAOYSA-N [3-(hydroxymethyl)-2-bicyclo[2.2.1]heptanyl]methanol Chemical compound C1CC2C(CO)C(CO)C1C2 YSVZGWAJIHWNQK-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000004520 agglutination Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 238000002815 broth microdilution Methods 0.000 description 1
- 210000002421 cell wall Anatomy 0.000 description 1
- 229960003260 chlorhexidine Drugs 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000004440 column chromatography Methods 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 230000002101 lytic effect Effects 0.000 description 1
- 239000000401 methanolic extract Substances 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 229940049954 penicillin Drugs 0.000 description 1
- 150000002989 phenols Chemical class 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 230000005180 public health Effects 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000006190 sub-lingual tablet Substances 0.000 description 1
- 229940098466 sublingual tablet Drugs 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000001550 time effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Chemical & Material Sciences (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Emergency Medicine (AREA)
- Cosmetics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP18217988A JPH01151512A (ja) | 1988-07-21 | 1988-07-21 | 齲蝕予防剤 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP18217988A JPH01151512A (ja) | 1988-07-21 | 1988-07-21 | 齲蝕予防剤 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP55161091A Division JPS5785319A (en) | 1980-11-16 | 1980-11-16 | Agent for dental caries |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH01151512A JPH01151512A (ja) | 1989-06-14 |
| JPH0217524B2 true JPH0217524B2 (en]) | 1990-04-20 |
Family
ID=16113723
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP18217988A Granted JPH01151512A (ja) | 1988-07-21 | 1988-07-21 | 齲蝕予防剤 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH01151512A (en]) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH02131526U (en]) * | 1989-04-01 | 1990-11-01 |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR0128494B1 (ko) * | 1994-07-26 | 1998-04-04 | 최무섭 | 색전이 없는 생약 추출물-함유 줄무늬 치약 조성물 |
| US6500409B1 (en) * | 2000-05-10 | 2002-12-31 | Colgate Palmolive Company | Synergistic antiplaque/antigingivitis oral composition |
| ATE525061T1 (de) | 2001-02-28 | 2011-10-15 | Axiomedic Ltd | Feste selbst-haftende zusammensetzungen zur topischen behandlung von störungen der mundschleimhaut |
| US7595065B2 (en) | 2002-06-25 | 2009-09-29 | Wm. Wrigley Jr. Company | Breath freshening and oral cleansing products with synergistic combinations of magnolia bark extract and essential oils |
| US7632525B2 (en) | 2002-06-25 | 2009-12-15 | Wm. Wrigley Jr. Company | Breath freshening and oral cleansing product with magnolia bark extract in combination with surface active agents |
| US7347985B2 (en) | 2002-06-25 | 2008-03-25 | Wm. Wrigley Jr. Company | Breath freshening and oral cleansing product with magnolia bark extract |
| US20060127329A1 (en) * | 2004-12-10 | 2006-06-15 | Colgate-Palmolive Company | Tartar control oral care composition containing extract of magnolia |
| US8900644B2 (en) * | 2004-12-22 | 2014-12-02 | Colgate-Palmolive Company | Oral care compositions containing compounds from magnolia and hops extracts |
| RU2504368C2 (ru) * | 2008-05-30 | 2014-01-20 | Вм. Ригли Дж. Компани | ЖЕВАТЕЛЬНАЯ ТВЕРДАЯ КОМПОЗИЦИЯ И СПОСОБ ПОДАВЛЕНИЯ РАЗВИТИЯ Streptococcus mutans |
| RU2526913C2 (ru) | 2009-08-12 | 2014-08-27 | Колгейт-Палмолив Компани | Композиция для ухода за полостью рта |
| MX2013001010A (es) * | 2010-07-29 | 2013-03-07 | Colgate Palmolive Co | Composiciones para el cuidado oral. |
-
1988
- 1988-07-21 JP JP18217988A patent/JPH01151512A/ja active Granted
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH02131526U (en]) * | 1989-04-01 | 1990-11-01 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH01151512A (ja) | 1989-06-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JPH0138084B2 (en]) | ||
| Muroi et al. | Combination effects of antibacterial compounds in green tea flavor against Streptococcus mutans | |
| JP7068286B2 (ja) | 防腐剤耐性乳酸菌 | |
| US8183215B2 (en) | Method of administering oral flora-improving agent, antibacterial agent and growth promoter | |
| JP2000512660A (ja) | 口腔衛生用製品のための抗菌剤 | |
| JPH0217524B2 (en]) | ||
| JPS6038329A (ja) | う蝕予防剤 | |
| JP4440095B2 (ja) | 抗歯周病菌組成物 | |
| WO2012001347A1 (en) | Products with oral health benefits | |
| JP2014047157A (ja) | 口腔用殺菌組成物 | |
| KR20170141053A (ko) | 치자나무 추출물을 포함하는 구강질환 예방 또는 치료용 조성물 | |
| KR20170141034A (ko) | 인삼 추출물을 포함하는 구강질환 예방 또는 치료용 조성물 | |
| JP5946608B2 (ja) | オートインデューサー−２阻害剤 | |
| JP7548240B2 (ja) | 口腔内の病原性細菌に対する生育抑制剤、口腔内の菌叢改善剤及び口腔用組成物 | |
| KR102289506B1 (ko) | 스트렙토코커스 뮤탄스 균에 대한 항균 조성물 및 이를 이용한 구취 제거용 조성물 | |
| JPH0639375B2 (ja) | 抗齲蝕剤 | |
| KR20170141030A (ko) | 시스타노사이드 에이를 포함하는 구강질환 예방 또는 치료용 조성물 | |
| KR102729343B1 (ko) | 에스트라갈로사이드를 포함하는 구강질환 예방 또는 치료용 조성물 | |
| KR102850121B1 (ko) | 락티카제이바실러스 파라카제이 ok 균주 및 이의 용도 | |
| JP7198547B1 (ja) | 予防又は治療剤、抗菌剤、及び口腔用組成物 | |
| KR102705932B1 (ko) | 락토바실러스 가세리 HHuMIN D 및 락티카제이바실러스 파라카제이 OK 복합 균주를 포함하는 구강질환 개선, 예방 또는 치료용 조성물 | |
| US20160367471A9 (en) | Compositions and methods for reducing caries-causing oral bacteria | |
| KR102217518B1 (ko) | 치주염 예방 또는 치료용 유산균 및 그의 용도 | |
| JPS59175428A (ja) | 抗齲蝕剤 | |
| JPH0672091B2 (ja) | 抗う蝕組成物 |